ChiralVision

Services - Enzymatic process development

Smart throughput:

ChiralVision is the specialist in route development comprising enzymatic conversions and resolution and has an extensive experience in process development and scale-up of enzymatically prepared chiral compounds. We can help you to develop new and proprietary routes to existing compounds, or take an existing synthesis and develop a scalable process, all with smart use of biocatalysis. By using only commercially available (bulk) enzymes, enzyme costs per kilogram of end product can be kept to an absolute minimum. Furthermore, because the enzymes are freely available on the market a steady supply and the lowest possible price is guaranteed. The target for enantiomeric excess is >99%.

New IP:

We can develop new and proprietary routes to existing compounds, or take an existing synthesis and develop a scalable process, all with smart use of biocatalysis. Once your project reaches the level of manufacturing you will benefit from seamless technology transfer as the team that guided your project through development follows it through commercial manufacturing.

Quick results:

Speed is one of the key requirements for safeguarding competitive advantages, both in developing new processes and in market launches. Enzyme screening for the selection of the best enzyme for a specific conversion is performed within the time frame of 2-3 weeks; optimization and initial scale-up of an enzyme-catalyzed reaction is performed in 3 weeks.

Many enzyme classes are available for the various biocatalysis services:

Hydrolases: synthesis of chiral amines, esters, alcohols, amides, carboxylic acids (lipases, esterases, proteases and amidases):

Ene reductase: asymmetric double bond reduction

Ketoreductase: asymmetric ketone reduction into chiral alcohols

Nitrile hydratases: synthesis of chiral amides from nitriles

Nitrilase: synthesis of chiral carboxylic acids from nitriles

Oxynitrilase: asymmetric synthesis of chiral cyanohydrins

ω-Transaminase: synthesis of chiral amines from ketones, ketoacids

It is ChiralVision's aim to make biocatalysis an available and affordable technology for the present day chemical manufacturers. With the knowledge we provide you can create new opportunities for innovations in your business.

*** info and pricing of chiral process development ***