Immobilization and purification of enzymes and proteins in general requires special carriers. ChiralVision offers carriers with high porosity and various binding modes for optimal immobilization and purification.
Our carriers with binding through epoxides, adsorption, cationic groups, anionic groups and His-tags cover the most important range of binding options.
In 1916 Nelson and Griffin immobilized invertase on charcoal. This discovery was the first of various enzyme immobilization techniques currently available.
For each immobilized enzyme optimization of activity and stability is performed. After immobilization, washing and drying an enzyme is obtained that can be used in water-free media and stored for prolonged times.
Once your project reaches the level of manufacturing you will benefit from seamless technology transfer as the team that guided your project through development follows it through commercial manufacturing.
ChiralVision provides custom immobilization, enzymatic process development and custom enzymatic chiral synthesis
We provide chiral process development and enzyme immobilization services to design routes to advanced intermediates such as unnatural amino acids and derivatives and active pharmaceutical ingredients.
Using enzymatic technology the target optical purity for high quality chiral intermediates is >99% e.e. for single chiral centres and >98% d.e. for compounds with multiple chiral centers.